Search results for "Nucleotide receptor"

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Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.

2014

AbstractNucleotides activating P2Y13 receptors display neuroprotective actions against different apoptotic stimuli in cerebellar granule neurons. In the present study, P2Y13 neuroprotection was analyzed in conditions of genotoxic stress. Exposure to cisplatin and UV radiation induced caspase-3-dependent apoptotic cell death, and p38 MAPK signaling de-regulation. Pre-treatment with P2Y13 nucleotide agonist, 2methyl-thio-ADP (2MeSADP), restored granule neuron survival and prevented p38 long-lasting activation induced by cytotoxic treatments. Microarray gene expression analysis in 2MeSADP-stimulated cells revealed over-representation of genes related to protein phosphatase activity. Among them…

MAPK/ERK pathwayAgonistmedicine.drug_classMAP Kinase Signaling SystemUltraviolet Raysp38 mitogen-activated protein kinasesDUSPp38Genotoxic StressCREBNeuroprotectionMAPK protein phosphataseModels Biologicalp38 Mitogen-Activated Protein KinasesNucleotide receptorP2Y13 receptorCa2+/calmodulin-dependent protein kinaseCerebellummedicineAnimalsPhosphorylationRats WistarReceptorMolecular BiologyCell NucleusNeuronsbiologyCell DeathCaspase 3Receptors Purinergic P2Dual Specificity Phosphatase 2Cell BiologyThionucleotidesNeuroprotectionCell biologyRatsAdenosine DiphosphateEnzyme ActivationNeuroprotective AgentsCytoprotectionbiology.proteinCisplatinDNA DamageBiochimica et biophysica acta
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